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A tracheostomy tube can profoundly impact ability to communicate.
Variations in CCN concentrations, say the researchers, can profoundly impact cloud properties with important effects on both regional and global climate.
In specific cases, such variability can profoundly impact the response of cell populations to therapy, in both antibiotic treatments in bacteria and chemotherapy in cancer.
The effect of parameter uncertainty on catalyst design is discussed; it is shown that adsorbate adsorbate interactions can profoundly impact materials design.
Moreover, we now recognize that variables early in newborn life like frequency of antibiotic usage, route of delivery (i.e. C-section or vaginal birth) and early diet (especially maternal breast milk and formula feedings) can profoundly impact metabolism with both short and long-term consequences.
It was observed that fat content and physical activities can profoundly impact the absorption of therapeutic proteins in an animal model (Wang et al., 2012).
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It has often been reported that increased ROS formation by DCA treatment can also profoundly impact mitochondrial membrane integrity causing a reduction in the Δ ψm and subsequent initiation of apoptosis in several cancers (Bonnet et al, 2007; Michelakis et al, 2008, 2010; Stockwin et al, 2010; Ziebart et al, 2010).
"We found that environmental stress can permanently and profoundly impact the connectivity of a developing nervous system," said Dr. Hobert, professor of biological sciences at Columbia University and a faculty member of the Department of Systems Biology.
Although most of the attention is on who will be hired where and when, how much buyouts and new contracts will cost, and how it will impact recruiting, there's one other area of college athletics that can be profoundly impacted by a head coaching change: facilities projects.
The duration, severity and impact of these symptoms vary tremendously from person to person and population to population, but menopausal symptoms can profoundly affect personal and social functioning in affected individuals.
This can profoundly affect the dynamics of volcanic eruptions.
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