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An individual can only be replicated in the right environment, not to mention that its replication involves material and energy coming from the environment.
It also doesn't help that the leprosy-causing bacterium cannot be cultivated in a laboratory (in vitro) and can only be replicated partially in mice (though armadillos are the other mammal, apart from humans, that can carry the disease).
The complex interplay between HLA genes and haplotypes can only be replicated in systems where these haplotypes are present.
It should also be noted that there is a particular problem with DNA at the end of a chromosome, which can only be replicated by forks coming from the body of the chromosome.
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It is commonly accepted that newly identified risk genes, such as those identified in genome-wide association studies of complex diseases, can only be established if they are replicated in independent study populations.
With the two major limitations of the small sample size and the fact that the CBT therapist administered outcome questionnaires, any conclusions can only be tentative until findings are replicated in a larger study with better blinding.
Consequently, large population sizes and many replicates can only be achieved in evolution studies with simple maintenance and rapid phenotyping.
Even in wealthy countries, it can only be controlled; antiretroviral cocktails keep it from replicating.
Based on their endoplasmic location and inaccessibility to cytoplasmically replicating viruses, TLRs can only be activated by viruses through endocytosis, or by phagocytic/autophagocytic uptake of viral RNA from the cytoplasm of infected cells.
Units replicated at the requester can only be supportive for the immediate neighborhood.
In the case of missing replicates, the variance that can only be calculated between the conditions, reducing the statistical power.
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