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Although fundamentally diverse, a central aspect common to both fields is that function can only be rationalized by considering dynamic equilibria between distinct states of the accessible free energy landscape.
Strikingly, we observed an additional XL between Hsp70 and Hsp90 (K271-K558) that cannot be reconciled with only one Hsp70, and can only be rationalized by antiparallel subunit interactions of a second Hsp70.
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Bilgrami (2006) argues that we can only be held responsible for actions if we know the beliefs and desires that "rationalize" our actions; since we can (by assumption) sometimes be held responsible, we must sometimes know our beliefs and desires.
However, such constant-force restraints in Steered MD can only be used to study intermediates at small extensions because for larger motions, it is difficult to rationalize the stability of the constant-force restraints.
Thus the observations with the fluorescent markers, taken alone, can be rationalized.
The traits of an individual can be rationalized not only as to how they helped an individual's ancestors compete with conspecifics but how they helped its species compete with other species.
Stable isotope fractionation (e.g., D/H) can also be rationalized in this manner.
How can this be rationalized?
This can also be rationalized as follows.
The observation can easily be rationalized using the orientation model for peptide retention.
Although the Protein Data Bank provides a steadily growing source of public domain 3D structures of therapeutically relevant proteins, only small numbers of activity cliffs can be rationalized in three dimensions and compared to 2D cliffs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com