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The phrase "can make a significant contribution" is correct and can be used in written English.
It is often used to express someone's potential or ability to make a positive impact or difference. Example: As an experienced researcher, I believe I can make a significant contribution to the field of science with my innovative ideas and strong work ethic.
Exact(58)
Reducing food waste worldwide can make a significant contribution to tackling climate change, the report said.
But Crime Stoppers can make a significant contribution to the work of cash-strapped police departments.
Collectively, they can make a significant contribution to halt the rise in diabetes and improve the lives of those living with the disease".
"Those of us concerned about climate change know that nuclear power, if it's safe, can make a significant contribution to the climate change question.
In an era of budgetary restraint with limited resources for training and development in the workplace, individuals and employers alike are realising how volunteering can make a significant contribution to personal and professional growth".
We want to be sure that culture can make a significant contribution to the success of the 2012 Olympics, when the eyes of the world will be on us.
While this will not feed the extra two billion people we can expect by 2050, being more resource efficient and less wasteful can make a significant contribution to future food security.
"After serious discussions with the Trump transition team, I feel that I can make a significant contribution particularly to making our inner cities great for everyone," Carson wrote in the post on 23 November.
In the majority of job adverts, departments are explicit in looking for people who can illustrate that their work can make a significant contribution to the Research Excellence Framework REFF).
"Our time on the UN security council shows that Australia can make a significant contribution in advancing the rights of women and girls, strengthening governance and democratic institutions, promoting freedom of expression, and advancing the protection of human rights".
We must do more to nurture those within the profession that can make a significant contribution as senior leaders and we must engage more effectively with the wider civil service leadership.
More suggestions(16)
can make a large contribution
can make a remarkable contribution
can make a major contribution
can make a tremendous contribution
can make a significant punch
can make a direct contribution
can make a disproportionate contribution
can make a genuine contribution
can make a useful contribution
can make a significant difference
can make a real contribution
can make a big contribution
can make a substantive contribution
can make a positive contribution
can make a constructive contribution
can make a net contribution
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com