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CAN involves autonomic nerve fibers innervating the heart and blood vessels, and consequentially represents a significant cause of cardiovascular morbidity and mortality in diabetic patients [ 1].
Traditionally, the diagnosis of CAN involves a number of tests, including the R-R response to deep breathing, postural changes and during Valsalva maneuver, or 24-h ECG recordings, which may be cumbersome to perform uniformly, especially in large multicenter trials such as ACCORD.
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