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Excessive hepatic fat accumulation during obesity and non-alcoholic fatty liver disease (NAFLD) can induce chronic endoplasmic reticulum (ER) stress, a perturbation in ER homeostasis that can lead to hepatocyte death and a subsequent series of liver inflammation, oxidative stress accumulation and fibrosis collectively known as non-alcoholic steatohepatitis (NASH 1,2.
These results demonstrate that P210bcr/abl expression can induce chronic myelogenous leukemia.
To determine whether P210bcr/abl can induce chronic myelogenous leukemia, murine bone marrow was infected with a retrovirus encoding P210bcr/abl and transplanted into irradiated syngeneic recipients.
Melgar et al. showed that a single cycle of high-dose DSS can induce chronic inflammation over time in wild type C57Bl/6 mice [24].
Overcrowding, or housing of animals in abnormal social groupings, can induce chronic stress from which individuals are unable to retreat [2].
Clearly, if work characteristics can induce chronic behavioural problems in horses, it could also affect their personality, as it does in humans [4].
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One more recently study by Atarashi et al. showed that strains of Klebsiella spp. from the salivary microbiota colonize in the gut and can potently induce chronic intestinal inflammation (Atarashi et al., 2017).
It can also chronicize or induce chronic intestinal functional disorders, 2 which could invalidate soldiers during their mission, especially when of short duration.
Considering that β‐GPA can induce a chronic activation of AMPK, we asked whether β‐GPA can extend the lifespan of Drosophila melanogaster.
It has been reported that premature ventricular contractions (PVCs) can induce a chronic, dry cough, presumably through transient increase in blood flow through pulmonary arteries [ 9].
It was reported that β‐GPA can induce a chronic activation of AMPK by increasing the AMP/ATP ratio in mice (Bergeron et al., 2001).
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