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A small number of families can have a devastating impact.
Aggressive, new species arriving from one region can have a devastating impact elsewhere.
Speaking at the briefing, Davies said mitochondrial disease can have a "devastating impact" on families.
An elephant raid on a crop plantation can have a devastating impact on family livelihoods.
"We know that these experiences can have a devastating impact on their lives.
Harmful mutations in mitochondrial DNA can have a devastating impact on children who inherit them.
"If untreated, these perinatal mental illnesses can have a devastating impact on the women affected and their families.
This means that big exchange-rate movements can have a devastating impact on a country's balance sheet.
As the Grenfell Tower fire showed, the lack of a powerful local voice can have a devastating impact.
And when federal funds are diverted to protect individual homes over timberland, it can have a devastating impact on their economy.
"If there are violations and problems it can have a devastating impact across the board, for all gene therapy research, at every institution," Dr. Caplan said.
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CEO of Professional Science Editing for Scientists @ prosciediting.com