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In addition, experience shows that such designed single-target drugs can generate problems of relapse, resistance, and mutations, due to the disease complexity, as well as an ability to avoid drug-affected pathways through use of alternative routes.
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The absence of bony structures or even differences in the number of bones, principally when accompanied by chromatic variability, can generate problems for the systematics of some taxa-and in order to avoid taxonomic errors it is necessary to recognize certain characters as being valid and take into account the magnitude of those variations.
But that technique generates problems of its own, including dust accumulation that can block air intakes and induce a figurative computer meltdown.
Urban woodland vegetation provides people with many aesthetic, ecological and psychological benefits, but can also generate problems concerning people's perception of safety.
The primary aim of this article is to show that the traditional aversion to density and the more recent uncritical acceptance of density can both generate problems.
Both of them can generate various problems.
Our system can generate instances of the problem using different distributions of client and mesh routers.
Nevertheless, recent technological innovations called next-generation sequencing, particularly the development of RNA-seq technology, have shed some light to this problem, which can generate tens of millions of short sequence reads.
Although the nature of such progenitor cells remains to be explored, in terms of the classes of neurons they can generate, such approaches solve the problems of lack of renewability of transdifferentiated neurons and, potentially, of reduced neuronal complexity.
Heuristic solution procedures can generate adequate approximations of the set of efficient solutions to complex problems in reasonable time.
The rich elemental composition of E. nuttallii associated with its high capacity for nutrient uptake [30, 31] can generate water quality problems due to the release of nutrients in autumn when the plants decay [10].
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