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Be careful of tight socks which can further impair peripheral circulation.
Extensive disease may require bowel resection as a necessary treatment which can further impair nutrient absorption and digestion.
Macrolides are also inhibitors of P-glycoproteins which can further impair colchicine elimination which is well reported [ 5– 7].
Concomitant use of diuretics and/or cyclosporin is common and can further impair uric acid clearance and increase the risk of gout attacks.
Moreover, patients with severe asthma often show a tendency to anxiety and depression, which can further impair disease control by reducing their compliance to prescribed medications.
In addition, activated inflammation and neurohumoral system can further impair hemodynamics and contribute to other organ hypoperfusion, including that of the kidneys [ 2, 3, 7, 12].
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In summary, OPA1 deficiency causes malfunction of ETC and results in elevated production of ROS, which in turn can further impaired the complex activity and mitochondrial bioenergetic capability and consequently accelerate aging in dOpa1+/− mutants.
A sustained production of reactive oxygen species during colonic inflammation can overwhelm the antioxidant defense system [ 26], which can be further impaired by iron supplementation.
In particular, the lean body mass, the levels of serum albumin, the blood flow to the liver, and the glomerular filtration rate are reduced in elderly individuals and can be further impaired by the concomitant presence of acute or chronic kidney disease.
During swelling or increased intracranial pressure, blood vessels can be further impaired due to compression of the surrounding tissue.
Excessive ROS levels can also induce cellular damage by interacting with DNA, lipids, and proteins [ 83], which may further impair vascular structure and function.
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