Taken together, our results suggest that the ability of TIGAR to down-regulate ROS levels can limit both apoptosis and autophagy, although autophagy itself can also function to decrease ROS levels and so lower apoptosis.
Previous in vitro studies have indicated that tankyrases influence telomere length in a telomerase-dependent manner [10], [26], and that interfering with tankyrase function can lead to decreasing telomere length, possibly through decreased access to telomerase (11 , 24.
Osteoarthritis of the wrist is a painful disease process, which can lead to decreased function and disability of the upper extremity.
Potential muscle and joint damage associated with severe burns can lead to decreased function.
p38 can function as a tumor suppressor; a decrease of p38 activity significantly contributes to tumorigenesis [ 74].
If rates are high enough, mercury in the air can lead to decreased cognitive functions, vision impairment, and developmental issues in children.
This can lead to decreased immune system function.
The presence of isoAsp residues in proteins has been shown to decrease protein function and can trigger autoimmune responses.
(5.9) Increasing the domain of definition of a function can only decrease its minimum.
Awareness of these resources will enhance the clinician's ability to accurately assess balance and gait, which can improve physical function, and decrease the risk of falls for both average-risk and high-risk older adults.
