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We also have determined that constructs with FOP ACVR1 mutations that are engineered without the ligand-binding domain retain increased BMP-pSmad1/5/8 pathway activation relative to wild-type ACVR1, supporting that the mutant receptors can function through ligand-independent mechanisms either directly through mutant ACVR1 or through indirect mechanisms.
This suggests that palmitate can function through actin cytoskeleton to transduce its apoptotic signal in β-cells.
From a cell-wide view, allosteric changes can function through a number of pathways which are communicated within, across and between cells.
With medical lighting, cell phone charging, and fetal monitoring provided by the Solar Suitcase, health clinics can function through the night.
Because antisense transcripts can function through small interfering RNA (siRNA) derived from paired sense antisense transcripts [29] [31], we investigated whether the negatively correlated antisense gene/TAR pairs could generate siRNA by Northern blot analysis using the cloned TARs as probes (Figure 5C 5E).
Different early adipogenic factors can function through the same transcription factor (PPARγ) to regulate adipocyte differentiation.
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Previous studies revealed that several S100 family members can function extracellularly through RAGE ligation [3].
This, therefore, provides strong evidence that the conserved regions can function to enhance methylation through base-pairing adjacent to the target site.
Beside mRNA cleavage, plant miRNAs can also function through translational inhibition that can decrease the level of target proteins [ 13, 14].
We know that the two hemispheres of the brain can function separately but communicate silently through the corpus callosum, he reasons.
"The female characters each state, in their own way, that you can only function through a man".
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