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This antibody can exert strong and selective DR5-dependent cytotoxic activity against MCSP-expressing melanoma cells.
Heterogeneous hydrologic, lithologic, and geologic basal boundary conditions can exert strong control on the evolution, stability, and sea level contribution of marine ice sheets.
Disease (Chapter 27) can exert strong selective pressures, create bottlenecks, and therefore be a source of important evolutionary novelties.
Due to its high solubility in comparison to mineral silicates, sediment and soil BSi can exert strong control on DSi concentrations in wetland pore water (e.g., Struyf et al. 2009).
This is related to the topographic variation in climate at the topo-scale environment that can exert strong influences on establishment patterns (Callaway and Davis 1998; Keyes et al. 2009).
Finally, while not all neutralization-sensitive Envs were CD4 independent, all CD4-independent Envs exhibited enhanced sensitivity to neutralization by HIV-1-positive human sera, indicating that the humoral immune response can exert strong selective pressure against the CD4-independent phenotype in vivo.
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IL-6 has long been considered an inflammatory cytokine, but it can also exert strong anti-inflammatory effect by boosting production of anti-inflammatory cytokines and inhibiting production of pro-inflammatory cytokines (Petersen and Pedersen 2006), and may act as a mediator of muscle healing (Toumi et al. 2006).
Among the many environmental stressors that drive adaptation, the presence of toxic chemicals--naturally derived or anthropogenic--can exert strong effects, in part through their ability to affect the survival of sensitive early developmental stages.
Therefore, overexpression of human wt-p53 can exert a strong inhibitory effect on human 14-3-3γ 14-3-3γ 14-3-3γ and tumors havingenet-p53 showexpressionexpression.
The ambiance of a listening space, that is to say, can exert a strong pull on listeners with only vague notions of what they are about to hear.
Theoretical and empirical results indicate that such compensatory interactions (intramolecular epistasis) can exert a strong influence on trajectories of protein evolution.
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