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The use of designed biomimetic platforms therefore yields insight into ECM mechanosensing by revealing that cells can engage distinct mechanisms to promote adhesion onto substrates with different time-dependent properties.
While previous work has demonstrated that β2ARs can engage distinct signaling and functional cascades mediated by either G proteins or the multifunctional adaptor protein, β-arrestin, the precise role of β-arrestin in skeletal muscle physiology is not known.
Proteins are composed of small units or domains that can physically interact together forming multi-domain protein regions; each region can engage distinct ligands, either simultaneously or at successive stages of signalling [ 8].
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Welle, C. G. & Contreras, D. Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry.
Interestingly, different drugs may engage distinct components of the apoptotic machinery (Milner et al, 2002).
However, several pieces of evidence indicate that different aversive contingencies may engage distinct neurobiological systems [ 16].
This represents a third mechanism by which ligands can engage Smo, one that is distinct from pure 7TM and CRD ligands.
My colleague Heidi Neck launched this series by pointing out that entrepreneurship is about "acting and doing," and that there are five distinct practices entrepreneurs can engage in to learn entrepreneurship.
We should follow the example of other U.N. member states, including some countries in the Caribbean as well as the U.K., and the Netherlands, and expand the U.S. contingent to include members of civil society -- people with a distinct viewpoint who can engage in the proceedings and represent the views of drug users.
Bnip3 induces cell death through at least two distinct mechanisms: Bnip3 can engage anti-apoptotic Bcl-2 family members to trigger Bax Bak-dependent OMM permeaBax Bak-dependentuce a nOMMl mitochondrial leak permeabilitynteracting with the orticantrophy-1 proteinducea1).
The second distinction pertains to two distinct ways in which one can engage in conceiving.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com