Indeed, prostaglandins have been shown to cause sensitization of peripheral sensory neurons (peripheral sensitization) [6] and to produce allodynic behavior [7], [8].
There could be interaction effects among allergens to cause sensitization and attacks and worsen the condition.
We assessed the possibility that chemical inhibition of NAMPT could also cause sensitization to olaparib.
This indicates that NO donor-induced nociception is dependent on both TRPV1 and TRPA1 (in another words, activation of either TRPV1 or TRPA1 by NO donors can cause acute pain after sensitization).
Recent studies showed that oxidative stress can cause peripheral and central sensitization and alter nociception [ 23], resulting in hyperalgesia mediated by both local and spinal oxidant mechanisms.
The knowledge that pre-transplant transfusions can cause human leukocyte antigen (HLA) sensitization dates to the early days of transplantation in the 1960s and 1970s [ 77].
Problems arise, moreover, when the fetus or infant is exposed to airborne pollutants such as ETS and diesel exhaust particles (DEP), which can cause airway inflammation and may enhance allergic sensitization and drive disease expression.
Respiratory irritants can cause syndromes that are clinically similar to those that result from respiratory sensitization and it can be difficult clinically to determine that an individual suffers sensitizer- versus irritant-induced respiratory disease.
This, in the long run, can cause further damage, exacerbate the symptoms through peripheral and central nervous system sensitization (lowering of pain threshold), and promote dysfunctional movement patterns [ 4, 10, 18].
Inhalation of ground-level ozone can cause health problems such as damage to lung tissue, reduction of lung function, and sensitization of the lungs to other irritants [5].
