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Since intracerebroventricular infusion of tetracycline solutions can cause overt acute toxicity in animals, we entrapped the drugs in liposomes.
Domestication of the mouse through international trading has also introduced over 60 infectious pathogens that can cause overt disease, as well as more subtle effects upon research.
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These findings in mice provide an example of how genetic and environmental factors that do not cause overt pathology on their own can interact to induce pathology resembling that observed in human disease.
Although cancer cells generate increased ROS, these ROS levels are still below that which cause overt damage41.
The current NHP aerosol model failed to cause overt signs of MERS-CoV infection.
We chose this dose since 10 mg/kg was reported not to cause overt sedation (18).
Loss of crb-1 does not cause overt defects in polarity.
Additional factors appear necessary for soy to cause overt thyroid toxicity.
In summary, CEM is minimally invasive, and it can be applied without causing overt mechanical or photochemical damage to motor axons and their terminals.
This is the defining characteristic of 'posterior fossa crowdedness', which can cause cough headache even in the absence of overt tonsillar herniation [15], as exemplified by Patient 14 in our series.
Therefore, such TEC can be readily handled without causing overt damage to the matrix-cell complex during implantation procedures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com