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FFP also is less expensive than targeted treatments, but can cause hypersensitivity reactions and rarely, worsening angioedema symptoms [21, 22].
Immunogenicity of therapeutic mAbs can cause hypersensitivity responses such as anaphylaxis and infusion reactions, and accelerated clearance of drug, resulting in decreased safety and efficacy (Chirmule et al., 2012).
The increased ROS in lower RTIs can cause hypersensitivity by deranging the respiratory tract epitels [ 14].
Any drug can cause hypersensitivity but antibiotics, diuretics and anti-inflammatory drugs are the most common culprits.
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ABC use can also cause hypersensitivity reactions, which are associated with transient and mild liver enzyme elevations [ 29], but they usually occur within 6 weeks of initiation [ 30].
Isocyanates can also cause hypersensitivity pneumonitis, contact dermatitis, and rhinitis, but these outcomes are less commonly reported (Baur et al. 1994; Musk et al. 1988).
Biting midges of the genus Culicoides (Diptera, Ceratopogonidae) are vectors of several viruses of veterinary relevance, and they can cause insect bite hypersensitivity.
Perhaps the most well-known example to date is HLA-B*57 01 HLA-B*57 01been identified to bind whichthase drugs: abeenvidentifiedan cause toe abindvir hypersensitivity syndrome (AHS), and flucloxacillin and pazopanib, withh bothreeuse drugsinduced liver injury (DILI) [8, 9, 15–18].
Vancomycin can cause two types of hypersensitivity reactions, the red man syndrome and anaphylaxis [ 2].
Vancomycin can cause two types of hypersensitivity reactions, the red man syndrome and anaphylaxis.
Abscisic acid hypersensitivity can cause growth retardation even in the absence of external ABA, as demonstrated by the brx-2 mutant in Arabidopsis, which displays retarded root growth, and ABF3 and ABF4 overexpressers, which show general growth defects under non-stress conditions (Kang et al. 2002; Rodrigues et al. 2009).
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