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The separation can cause deep emotional stress.
Failure to get into top colleges, perform well at school or climb the economic ladder can cause deep shame and embarrassment.
The local beggars do well, but discrepancies between expatriate staff and, say, impoverished local officials trying to do the same work can cause deep antipathy.
The child psychologist Bruno Bettelheim, who readily acknowledged that the version of negative conditional parenting known as time-out can cause "deep feelings of anxiety," nevertheless endorsed it for that very reason.
"These type of protests can cause deep heartache," even though they may not always translate directly into sales figures, said Eric Denzenhall, the president of a crisis public relations firm in Washington.
So it is a feeling which can cause deep bias and irrationality towards others, the study points out - and science should think twice before administering the hormones linked to empathy as a form of medical intervention.
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Cliver et al. (2000) argued that while the RM effect causes stronger maxima at equinoxes (such as mountain building) the equinoctial hypothesis can cause deeper minima in solstices (such as valley digging).
The complicated clinical course results from increasing resistance in S. aureus isolates and also because the bacteria can cause deep-seated infections and sepsis [ 3, 4].
The Nice guidelines still advocate methods that can only cause deep distress.
Superficial infections of the mucous membranes and skin are most frequent, but Candida can also cause deep invasive disease, including septicemia, endocarditis, and meningitis.
This poses great challenges for persons with disabilities worldwide and can not only cause deep social and economic marginalization, but also lead to devastating outcomes during natural and chronic disasters such as earthquakes, floods or spontaneous building collapses and fires.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com