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This study demonstrates that a confluent monolayer of endothelial cells (ECs) can be tissue engineered on a soft substrate with a cell density and morphology that approximates in vivo conditions.
One important factor can be tissue specificity.
It can be tissue- or cell type-specific.
Disease-associated epigenetic variation can be tissue or cell specific.
Their expression is developmentally regulated and can be tissue- and cell-type specific [ 197].
In rheumatology, biomarkers can be "tissue fingerprints" or combinations of "neo-epitopes", reflecting catabolic effects downstream of inflammatory signals.
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This study demonstrates that vascular patches can be tissue-engineered with autologous BMCs and decellularized tissue matrices.
Of the four MEF2 members, all can be tissue-specific alternatively spliced, producing multiple isoforms which have significant functional differences [1] [4].
Interestingly, we detected an opposite trend in hippocampus tissues, suggesting that domain-wide expression changes during disease progression can be tissue-specific (Figure 7B).
These MSCs can be tissue-resident or be recruited from the bone marrow.
However, functional effect of eQTLs can be tissue-specific because transcription factors are often tissue-specific.
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