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Certainly, there have already been complex traits-ones undoubtedly shaped by many genes-that can be substantively altered by changing one gene.
In other words, some victors' justice can be substantively flawed.
Efficiency analyses can be substantively affected by the presence of outliers, which is why we tested the sensitivity of our results to outliers.
The defenders of the traditional conception of akrasia as irrational thus wish to grant special rational authority (in this procedural sense) to the agent's better judgment, even if they admit that such a judgment can be substantively incorrect.
Nevertheless, for gene function and drug discovery purposes in a high-throughput screening experiment, finding features with a small effect can be substantively important and a ranked list of candidate features, based on their significance, are often helpful.
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However, even if such losses can, as a class, be justified as retributive punishments, individual instances of them may be substantively unjustifiable (see, e.g., Lippke 2001, on the loss of the right to vote).
Thus condition (iii) cannot be substantively improved upon.
We ran models without these observations and still found the results to be substantively unchanged.
If you use these checklists, your work will be substantively better.
But this policy may actually be substantively worse for the public.
Though viewership is down and George Will calls the process "execrable and puerile", we agree that SOTUs can be consequential politically and substantively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com