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"can be substantially changed" is a correct and usable phrase in written English.
You can use it when you want to express that something has the potential to be drastically altered. For example, "The landscape of the city can be substantially changed with the addition of a new park."
Exact(2)
The properties of metals can be substantially changed by various heat-treatment processes.
The initial axial tilt of a planet determined by giant impacts can be substantially changed by stellar tides if the planet is close to its star and by satellite tides if the planet has a large satellite.
Similar(58)
How can you feel confident in people who frequently bring forward half-baked policies that have to be substantially changed within a few weeks of their announcement?
That may be true, Democrats and some Republicans say, if the tax package is substantially changed.
Later this picture was substantially changed.
No other results were substantially changed.
The UN's Intergovernmental Panel on Climate Change concluded in its latest comprehensive report on the state of global warming that "emissions can be substantially lowered through changes in consumption patterns … and dietary change and reduction in food wastes".
It is, nevertheless, and exciting avenue with potentially far-reaching implications when it comes to regulation of cardiomyocyte cell death, particularly in the contexts of a delayed and slow-progressing response outcome of which can be substantially affected by changes in cell-to-cell variability.
In the presence of stroma, however, the magnitude of the change can be substantially smaller, depending upon the amount of non-cancer tissue present.
This investigation has been the first to demonstrate that patients' self-report of their own HRQoL can be substantially altered despite no actual change in their underlying health state occurring (Table 2 and Figure 1).
In these cases, genetic variability can be substantially reduced through inbreeding (mating between close relatives) and genetic drift (random changes in gene frequencies).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com