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The mechanism by which our drugs reduce TPH expression can be speculated on the basis of previous reports.
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The current study cannot establish causal pathways, but potential explanations can be speculated on.
On the basis of the above results, it can be speculated that the feather-like ZnO hierarchical structures were synthesized via a two-stage nucleation-growth process.
Although the biological basis for this heterogeneity remains largely unknown, it can be speculated that the clinical response encompasses systemic effects as well as effects on the target tissue, the synovium.
Based on these findings, it can be speculated that such an interplay could be at the basis of mesenchymal alterations giving rise to skeletal, cardiac, and hemopoietic abnormalities observed in NS and other RASopathies.
On the basis of rs-fMRI findings, it can be speculated that MrD plays a double role in the neuromodulation of migraine (Fig. 4).
On the basis of these observations it can be speculated that a reduction of 12/15-LO 12/15-LO Xshould be activityctive target to reduce angiotenshould-mediated oxidative stress, vascular inflammation, cell proliferation and endothelial dysfunction [ 37- 39].
On the basis of overall these findings it can be speculated that NO endogenously produced by basal eNOS in white adipocytes is not involved in the modulation of adipogenesis-related mitochondrial biogenesis and adipogenesis itself.
Moreover, on the basis of isolation of cytotoxic H. pylori strains from ulcer patients, it can be speculated that cytotoxin causes severe damage to the gastric epithelium.
On the basis of these in vitro data, it can be speculated that even identical amounts of progesterone may result in different anti-inflammatory effects in females as compared with males.
The relevance of this observation on patient outcome can be speculated only.
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