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From a clinical perspective, one of the most important characteristics of epigenetic modifications is that they can be reverted using enzymatic treatments (such as DNMT and HDAC inhibitors).
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This study has associated limitations that include the limited period of 1 year of COC use and the lack of BMD evaluation in adolescents with interrupted COC use, which could have indicated whether inappropriate bone mass incorporation associated with COC use can be reverted.
After the high-rate cycling, its discharge capacity at 0.2 C can be reverted to 97.67% of its initial capacity.
Epigenetic gene silencing is an attractive drug target due to the fact it can be reverted.
- Moreover, Tau acetylation can be reverted by SIRT1.
Such reduction beyond the optimum can be reverted by a 30 min flush with hydrogen peroxide.
The deleterious effect of a mutation can be reverted by a second-site interacting residue.
Similar to DNA mC-methylation, also RNA mA-methylation can be reverted.
In fact mitochondrial fragmentation can be reverted by genetic or pharmacological inhibition of calcineurin.
- Importantly, tumor-residing pDCs can be reverted into pDCs with tumoricidal activity when strong activation stimuli are applied., These studies highlight the potential of exploiting pDCs similar to the use of myDCs for anti-tumor therapy.
The relevance of GSCs as a therapeutic target has been highlighted because their stemness phenotype can be reverted.
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