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However, when individual randomization is not possible or desirable, groups of individuals can be randomized to intervention or control groups [ 14].
Since subjects can be randomized to one black box or another, no new methods are required.
This latter strategy has been shown to be less efficient because the patient can be randomized to the same therapy on either arm, diluting comparisons.
These trials include the international Medical Research Council RADICALS trial (NCT00541047) 31 where patients can be randomized to either early postoperative radiotherapy or deferred radiotherapy given at the time of biochemical failure.
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In general without constraints on system eigenvalues, an input can always be randomized to ensure that the state can be reconstructed with probability one.
With this information in hand, participants can then be randomized to control or treatment groups within each phyletic clade (or population).
However, conducting a RCT in relation to HA is not possible in Sweden since those that are assessed as requiring HA have a legal right to receive it; they can therefore not be randomized to a non-intervention group.
In the population studied, the presence of multiple comorbidities introduces the possibility that patients in the cBMA Group with delayed healing had suboptimal numbers of progenitor cells in their cBMA sample; a larger sample size will be required as well as prior progenitor cell analysis so that patients can be randomized according to progenitor cell number.
Although not detailed herein, we also parameterize different agent birth and death rates and probability of game interactions in addition to strategies that can be randomized individually or in combinations to isolate dynamics in any specific subcomponent module.
The flow of patients in this study is limited by the three different informed consents and agreements patients have to sign before they can be randomized for the RCT.
For the design of libraries that ideally contain a high percentage of well-folded clones to guarantee the efficient selection of binders, it is important to know those amino acids that can be randomized without significantly decreasing the conformational stability of resulting variants.
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