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While this is understandable, given the need to act and make a difference, and thus reduce complexities to concrete activities ("Let's get on, we're doing responsible development, we're OK"), it can be problematical, already because of the lock-ins (i.e. path dependencies) while society (and technology) change.
It has been pointed out that early morphological studies were erroneous; using skeletons from stuffed specimens can be problematical, as early taxidermists sometimes used donkey and horse skulls inside their mounts when the originals were unavailable.
However, our figure is higher than the 3.5 7.3% incidence suggested in a systematic review [4]; this may be explained by the fact that pooling data from ADR studies with different designs can be problematical [23], [24] as illustrated by the widely differing estimates of ADR incidence determined in different studies in different populations (from 0.86% [25], to 37% [26]).
It has been noted previously that reproducing reported R values for low-resolution structures can be problematical [8]. Figure 9A shows a superposition of the Cα backbones for refined models of an αβ-tubulin heterodimer, while Figure 9B focuses on the region of the bound colchicine.
It has been suggested that the clinical interpretation of 'broad-range' 16S rRNA PCR and sequencing results can be problematical e.g. the protocol has the potential to detect all bacterial DNA present in a given clinical sample, including non-viable or even degraded organisms.
It is well accepted that the initial processing of mycobacterial samples can be problematical compared to eukaryotic cells.
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Faint supernovae suspects (especially those fainter than visual or red mag 19) can also be problematical.
This can be particularly problematical when they wield substantial power over others.
It is common and approved practice, in charging a conspiracy, to name all who may be reached with process and whom it is anticipated the proof will connect with the scheme, although in most instances whether it will so turn out for each defendant can be only problematical.
This can be especially problematical for rare alleles, which typically dominate polymorphic sites.
Although null alleles can be recognised with some platforms, and controlled for [ 33, 34], they could be problematical where not anticipated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com