There is a three-point continuum on which this can be based: efficacy, effectiveness and efficiency (Fig. 1).
They demonstrate that many of the challenges we face are inter-connected and can be optimised for efficacy, spread and speed of growth.
Indeed, when it comes to selling skin care products and cosmetics, longevity can be perceived as efficacy.
Three major criteria eventually decide if a drug can be marketed: safety, efficacy, and mechanism of action.
While it is not illegal to sell these products (and there are some perfectly legitimate sources where they can be bought), the efficacy of what some marketers claim these products can do is widely debatable.
In combination with experimental or simulated pharmacokinetic data, therapeutic ranges for the drugs included in the model can be evaluated and efficacy and safety limits can be determined.
Thus, no conclusions can be drawn regarding efficacy of DR-management.
An increase in number of apoptotic cells was slight, however significant, which can be explained by efficacy of gene silencing.
It will be of interest to determine whether such differences, if observed, can be related to efficacy.
At this time, no recommendation can be given regarding efficacy and side effect profiles of systemic corticosteroids because clinical trial data are not available.
