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This figure not only illustrates pathway collaboration by showing their coordinating relationships, but it also shows that mutations are well distributed across the genes in each pathway, as an example of our hypothesis that any genes with functional mutations can be driver genes.
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Contradictions and tensions between activities are not necessarily negative and can be drivers for growth and change within the system (Doll and Trueit 2010).
However, some of the infrequent mutations can be drivers by functioning through a much more limited number of the same signal transduction pathways.
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