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Given that it has been shown that superenhancers can be disrupted using BET-bromodomain inhibitors, such as JQ1, it makes patients with MYC rearrangements good candidates for treatment with this class of drugs.
Homing has been shown to be dependant on spatial specificity determined by desmosomal proteins and can be disrupted using peptides to myoepithelial specific desmoglein-3 and desmocollin (Dsc) 3 [ 25].
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The cell suspension was disrupted using Constant Cell Disruption Systems Constant Systems Ltd , Warwick, UK).
Cells were disrupted using a glass homogenizer and plated.
The hip4+ ORF was disrupted using one-step gene replacement.
The study took into account the education of the participants, which can be disrupted by drug use.
The gut microbiome, composed of the microflora that inhabit the gastrointestinal tract and their genomes, make up a complex ecosystem that can be disrupted by antibiotic use.
In addition, specific associations of proteins can be disrupted by the use of detergents, so that protein components that could be of interest could be discarded and missed.
Rimonabant, a selective type 1 cannabinoid receptor (CB1) antagonist, may assist smoking cessation by restoring the balance of the endocannabinoid system, which can be disrupted by prolonged use of nicotine [ 52].
This natural regulation can be disrupted by the over-use of broad-spectrum insecticides or by the migration of S. frugiperda, since migrating populations can escape natural enemy control [ 24].
The tumorigenic effect of the cooperation of loss of BRCA1 with gain of EGFR in nonmalignant MECs can be disrupted by the preventive use of the EGFR inhibitor erlotinib.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com