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Established sequences can be considered by using weighted constraints.

Spectral information can be considered by using instrument models when the instruments are known in advance [28, 29].

Thus, the distribution direction can be considered by using the within-class scatter matrix S w in Equation 13.

These effects can be considered by using geochemical codes that implement algorithms that calculate the density of a fluid based on the concentration of individual solute species.

The desolvation effects can be considered by using implicit solvent models like the Poisson Boltzmann/surface area (PB/SA) model (Baker et al. 2001; Grant et al. 2001; Rocchia et al. 2002) and the generalized-Born/surface area (GB/SA) model (Still et al. 1990; Hawkins et al. 1995; Qiu et al. 1997).

Since Latin hypercube sampling is more efficient and robust than simple random sampling [29, 30], and correlations between variables can be considered by using the correlation matrix during the pairing process [31], Latin hypercube sampling with the Cholesky decomposition method is used to generate samples according to their correlation.

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Our algorithms allow one to consider more general retinal motions such as scale and rotation about the optical axis of the eye, but only simple translational motion can be considered by usually used patch-based cross-correlation algorithm.

Nevertheless this estimate represents a much larger number of modification types than can be considered by commonly used, but often restrictive PTCM search algorithms such as Sequest, X!Tandem, and Mascot [ 12- 14].

The second-order polynomial transformation allows one to consider more general motions such as scale and rotation about the optical axis of the eye, but only simple translational motion can be considered by usually used patch-based cross-correlation algorithm [ 13].

While many types of SLOs can be considered by RAP, we use an SLO based on a target mean application request response time in this paper.

Because practically all hip fracture case subjects will seek medical attention immediately and the majority of case subjects are hospitalized for surgical intervention, our capture of hip fracture incidence in this cohort can be considered complete by using linkage with this comprehensive nationwide hospital database that was established 3 years before the initiation of the cohort study.

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