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Considering the beneficial effects of aldosterone blockade on improving nitric oxide availability, endothelial function, and atherosclerosis, it can also be postulated that an aldosterone blockade would add to the benefits of an angiotensin-converting enzyme inhibitor in patients who have coronary artery disease.
In line with these findings, it can also be postulated that the use of different agents leading to GSH depletion (such as isothiocyanate and aziridine analogues) may express therapeutic potential to sensitize cells when combined with ROS-generating chemotherapy through drugs such as Fe-SP.
A similar mechanism can also be postulated for the soldier sub-group - which has many internal connections.
For the relationship between education and the item 'anxiety/depression' two antagonistic mediating mechanisms can also be postulated.
Similarly it can also be postulated that dogs with many calcifications are at a greater risk of getting clinical IDD than dogs with only few calcifications.
Thirdly, mechanisms other than that of a multi-stage process can also be postulated to account for the observed relationship and one has, in fact, been suggested by Fisher and Hollomon (1951).
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High-dose statin therapy may be hepatotoxic and may cause peripheral neuropathy, and it has also been postulated that it can promote tumor growth, particularly in women [4] [7].
It has also been postulated that damaged endothelium can impair cerebral autoregulation and thus lower the threshold for dysregulation [ 6].
It has also been postulated that CAR function can be modulated by the fatty-acid-sensitive transcription factor PPARα [ 33, 34].
However, it has also been postulated that factors operating among species can generate trends at higher levels.
TGA factors have also been postulated as redox sensors35 because cysteine modification can modulate their binding to NPR1 and to DNA36,37.
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