Besides this activation pathway, proMMP-2 can also be activated by thrombin and activated protein C (Nguyen et al. 2000).
Furthermore, MAPKs can also be activated through the upstream activation of HER2/neu or RAS.
The EGFR family members can also be activated by ligand-independent activation (Siwak et al, 2010).
The TSC1/2 complex can also be activated by energy depletion through the activation of AMP-activated kinase (AMPK).
Besides LKB1 activation, AMPK can also be activated by CaMKKβ, which is stimulated by intracellular calcium (Carling et al. 2008).
Recent evidence for a FasL-independent activation of Fas suggests that the death receptor can also be activated intracellularly, in the absence of its ligand [2].
However, it can also be activated as a second screen companion to the main action.
A swipe to the right reveals Google Now, but Google's search can also be activated from any home screen by tapping in the search box at the top of the screen or by simply speaking the words "OK Google".
The ad can also be activated through in-text ads.
The proteasome can also be activated in response to IGF-I in cell cultures.
Platelets can also be activated by ischaemic blood flow disturbances in the septic kidney.
