Sentence examples for can alkylate active from inspiring English sources
Halomethyl ketones can alkylate active site His residues and the activated ketone has been proposed to form a transition state analog at the active site.
These intermediates can alkylate biomolecules like lipids, heme and parasite enzymes including the ATP-dependent Ca2+ pump located on the endoplasmic reticulum, PfATP6.
Nitrogen mustard derivatives as DNA alkylating agents can alkylate DNA via interstrand or intrastrand cross-linking (ICL), leading DNA lesions.
To inhibit the abundant DUBs, they treated the extracts with NEM, which alkylates active-site cysteine residues.
HN1 can extensively alkylate cellular DNA but can only produce monoadducts and only shows cytotoxicity at very high concentrations compared with bifunctional HN2 (the LD80 were 1000 and 10 μM for HN1 and HN2, respectively).
Unlike conventional alkylzinc reagents these heteroleptic compounds can directly alkylate (tert-butylate) benzophenone in the challenging para position.
Thus, we surmise that these species could alkylate the active site of EGFR, thereby irreversibly blocking its action and that DNA damage could be induced by the methyldiazonium.
We have arrested Env activation at a stage prior to isomerization by alkylating the active thiol in SU and compared the structure of isomerization-arrested Env with that of native Env.
6, 52 However, the sPLA2-IB inhibitor used in that study, p-bromophenacyl bromide, also alkylates the active site histidine that is conserved in all sPLA2s and most likely inhibits multiple sPLA2s.
Metabolism of tamoxifen also involves formation of quinone metabolites, which can oxidise and alkylate cellular macromolecules in vivo (Zhang et al, 2000).
