Sentence examples for camp activation from inspiring English sources
Due to its several favorable physiological functions, including ASM relaxation activity, cAMP activation capability, and in vivo anti-asthmatic efficacy, 4e is a promising remedy for bronchial asthma, meriting extensive development.
PKA-independent effects are mediated by PI 3-kinases-Akt signaling and EPAC1 (exchange protein directly activated by cAMP) activation.
This causes a decrease in cellular cAMP, activation of the p38 mitogen-activated protein kinase (MAPK) pathway, and/or activation of ion channels.
Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].
Binding of the C2 domain of the CC2D1A to a membrane phospholipid [ 17] might cause conformational changes in CC2D1A exposing the (S) residue of PDE4D5 that in turn will be activated by the catalytic subunit of PKA that is released after cAMP activation.
In this scheme, cAMP activation of PKA induces encystation and prevents excystation.
The hierarchy can be quantitatively explained by differential CRP-cAMP activation of the promoters.
Importantly, though, SAG1-C65-HA apical redistribution and ciliary entry upon db-cAMP activation were blocked in the DHC1b-depleted fla24 gametes.
The classical β2-adrenoceptor signalling pathway through G α-AC-cAMP activation is, at least in part, responsible for the β2-adrenoceptor-mediated hypertrophy in the skeletal muscle (Navegantes et al. 2000, 2002, Hinkle et al. 2002).
Thus, if you wish to support this statement, you could record mouse ICatSper changes with 8Br-cAMP and show that 8-Br-cAMP activation is nonspecific, perhaps by showing a dose response curve, comparing inside and outside perfusion of the analog, etc.
Previous studies have demonstrated that the Dictyostelium G alpha subunit G alpha 2 is essential for the cAMP-activation of adenylyl cyclase and guanylyl cyclase and that g alpha 2 null mutants do not aggregate.
