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At the front are flexible panels called leading edge slats.
In this method, the enrichment of a pathway is mainly driven by a group of genes that are called "leading edge genes" (see Material and Methods).
Core genes or miRNA targets ranked at the top or bottom of each pathway gene list were most significantly altered between tumors and normal adjacent tissues (called leading edge in GSEA).
This paper concentrates on predicting broadband fan noise interaction (also called leading edge noise) and demonstrates that a random particle mesh method (RPM) is well suited for simulating this source mechanism.
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In this paper we fill this significant gap by proposing and evaluating a continuous analog to the lead user construct, which we call leading edge status (LES).
Since the differentially expressed genes are rank ordered, the procedure also returns so-called leading edge genes for which enrichment has its maximum value.
It's a lovely idea but I guess most people would regard it as an example of what one might call leading-edge uselessness.
That's called leading by example.
Meteorologists call the leading edge of an advancing mass of relatively cold air a cold front.
A humpback's flippers have a row of bumps called tubercles along their leading edge.
Motile cells extend dynamic fan-shaped pseudopods called lamellipodia at the leading edge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com