Within LCD1, a short segment called Conserved N-terminal Motif (CNM) (aa 72 89 for LATS1 and 71 88 for LATS2) is important for membrane recruitment and activation of LATS1/2 by Merlin/NF2.
Several of these enhancers are conserved in sequence with other gnathostomes as demonstrated by phylogenetic footprinting, and they are thus called conserved non-coding elements (CNEs).
The rapid increase in the number of genome sequencing projects [3] has resulted in a growing number of so called "conserved hypothetical protein families" which denote predicted proteins conserved across a number of organisms, but without detectable sequence similarity to proteins of known function.
About a third (70) of those sequences were also found in other insects that had been subjected to high throughput sequencing for small RNAs, such as L. migratoria [20], A. pisum [21], B. mori [19], [40] and C. quinquefasciatus [13] (Table S5); these are herein called "conserved" candidates.
Such sites were called "conserved sites".
The aligned human-mouse segments outputted from CHAOS are called conserved segments.
Collectively these sequences are called conserved non-coding sequences (CNSs) [ 11].
Here we test a specific subset of these markers called conserved ortholog set II (COSII) markers in the sister clades potato and tomato [ 37].
Finally, sites that satisfy all the above requirements are either called conserved or mutated, based on the event that took place between the human chimp ancestor and human.
In this paper, we propose a novel method called conserved gene cluster phylogenies (CGCPhy), which removes the genes potentially involved in HGT events, for inferring prokaryotic phylogenies.
And this is irrespective of the particular genome - it's the so- called conserved hypothetical set of genes in any given genome.
