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In such trials, additional phantom measurements are commonly performed to check whether calibration differences across the different involved scanners remain within tight limits so that SUVs derived at different sites are consistent and can be pooled during evaluation of the trial data [8, 9].
Otherwise, existing systematic calibration differences between sites need to be corrected by suitable cross-calibration factors between the different centers/PET systems to enforce data consistency [10].
While the presented approach to monitor group-averaged BSUV to account for a potential drift in scanner calibration or inter-site calibration differences can eliminate systematic bias from tumor SUV evaluations, it obviously is not able to account for actual inter-individual differences of BSUV (causing spurious differences in lesion uptake).
Therefore the blood shifts we measured during quiet breathing could not have resulted from minor calibration differences between the OEP and WBP signals.
Still, it is important to evaluate whether such item calibration differences will have an impact when comparing measures between diagnostic groups.
As expected, the use of different calibrations resulted in different time estimates, and although the penalized likelihood method (SGGPL) showed the greatest sensitivity to calibration differences, most methods yielded similar time estimates.
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Recent comparisons of calibrated AGAGE CH2Cl2in situ measurements with NOAA flask data at Mace Head show an absolute calibration difference of 8.8±4%4%, with NOAA data higher.
Moreover, evidence suggests that a 10 beat per minute or less tempo-pace calibration difference falls within thresholds by which patients can feasibly adjust their walking/running pace to accommodate to sonic and music rhythms by subconsciously increasing or decreasing their strides accordingly [18].
As proportionately higher enzymatic values (within biological criteria) were also observed in a method comparison experiment (part of the method validation) using random urine samples from adults, this is probably to a large extent caused by a calibration difference.
One was Master scaling, which involves calibration for differences in mean ratings as well as the slope of the psychophysical function for seven levels of a pink noise reference sound.
Apart from its effect on calibration, prevalence differences greatly affect the PPV of rapid diagnostic tests.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com