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The study calendar (Table 3) displays the timing of the activities with each participant in the trial and the natural history cohort.
At the central examination site, age was verified once again against an events calendar (Table 2), and if a person was thought to be below the age of 40 years, he/she was examined but not included in the survey sample.
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The years of the Julian period are not now used, but the day number is still used in astronomy and in preparing calendar tables, for it is the only record where days are free from combination into weeks and months.
The prescription pattern of drugs also changed during the study period (lithium was prescribed more rarely and antipsychotics and anticonvulsants more often in the recent calendar period, Table 1) but it is not clear how this relates to diagnostic habits or treatment-seeking behavior of subjects.
In additional analyses, we estimated the excess mortality rate according to age and calendar time (Table 2).
For both cohorts, the proportion of immigrants increased with calendar time (Table 1).
The cohort was divided into four sub-cohorts according to calendar time (Table 4).
However, higher comorbidity level was consistently associated with relatively lower survival in all four calendar periods (Table 3).
The overall median age at seroconversion was 33years (IQR: 2739) without major changes over calendar periods (Table 1).
There were no notable differences between sexes or age groups after the gastrectomy, while the SIR was higher in the later calendar period (Table 2).
Compared to patients with Charlson score 0 the MRRs increased with increasing level of comorbidity in each calendar period (Table 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com