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Power calculations were computed using Q uanto version 4.02 (Gauderman et al. 2002) (Fig. S1).
All statistical calculations were computed using GraphPad Prism4 software and significance was determined if P ≤0.05.
All statistical calculations were computed using the Epi Info™ Version 7.0.8.3 (Clifton Rd, Atlanta, GA, USA).
Statistical calculations were computed using graphpad prism version 5.01 for Windows, GraphPad software (San Diego, CA, USA).
These calculations were computed using descriptive statistics reported in original papers, which included variant frequency, effect size, odds-ratio and percent variance accounted for.
Lignan calculations were computed using different databases in the three studies and this, together with possibly different food sources, may have explained, at least in part, the discrepant findings.
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The calculation was computed using Power Analysis and Sample Size 11 software.
Combined quantum mechanical and molecular mechanical (QM/MM) calculations were used for the p Ka calculation, while the binding free energies were computed using pure molecular mechanical potentials.
The values of the total dipole moment and the first order hyperpolarizability of the investigated compound were computed using B3LYP/6-311++G d,p) calculations.
Biological efficiency (BE) values were computed using the following calculation: fresh mushroom weight divided by dry substrate weight and multiplied by 100.
Expected mortality rates for APACHE II and SAPS II scores were computed using the logistic regression calculations suggested in the original reports [ 26, 27].
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