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The presented software allows to apply the supercell approximation systematically with an all-in-one implementation of algorithms for structure manipulation, supercell generation, permutations of atoms and vacancies, charge balancing, detecting symmetry-equivalent structures, Coulomb energy calculations and sampling output configurations.
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The detail of the sample size calculation and sampling techniques was described else where [ 32, 33].
The current study suggests solutions to some limitations of existing admixture mapping methodologies, such as considerations regarding the distribution of ancestry information along the genome and its effects on power calculations and sample size.
The effect measure has to be determined in the early planning phase of the study since it enables to fix the statistical study plan regarding power calculations and sample size determinations [ 15].
For power calculations and sample size determination, a conservative assumption was made that the waitlist control group would show improvements, possibly due to increased awareness of mental health issues, of about 50% of that of the experimental group.
The sample size calculation and sampling method were based on the requirement of the trial, with townships as the randomisation unit (8 townships per group).
In absence of anterior results, reliable power calculation and sample size determination are not possible.
We used STATA software (version 13) for power calculation and sample size.
The resulting correlation indices (see 'Materials and methods' for calculation and sample sizes) were plotted in confusion matrices showing all possible combinations of birds and call types.
None of the studies reported a power calculation, and sample sizes were very small in some of the RCTs (ranging from 8 to 57).
Considering the power calculation and sample size of the present study, we conclude that there is no association between the CHL1 gene and AIS predisposition in a Han Chinese population.
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