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When performing the a priori power calculation we did not calculate with non-responders.
What we're going to do is redo the calculation we did before starting with Serena.
Due to the excessive resources required for the calculation, we did not explore the largest dataset with the likelihood approach.
Regarding the cost calculation we did not consider discounting or inflation that would have affected the cost differences proportionally.
This is illustrated by a power calculation we did assuming log‐normal distributions and a CV of 0.88 (taken from our LMAN data) (Author response image 1A).
In our sample size calculation we did not take into account the clustering effect induced by the design (randomisation of clusters).
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In our calculation we do not need to assume that the total hemoglobin is contained entirely in the microvessels.
Therefore it does not matter if the tangential part of any poloidal current system is included or not in our calculation; we do not need to make the toroidal/poloidal separation before integration.
As introduced in Section 2, we assume that ξ=a ξ 1+b ξ 2, ξ 1 and ξ 2 are I.I.D sequence, the non-Gaussian colored noise ξ has the same characteristic exponent α with S αS, and a different dispersion scale γ nov. To simplify the calculation, we do not consider the specific value of γ nov, and assume it is a known parameter.
30 As it is almost certain that clinicians practising in a contemporary ED with access to contemporary biomarker assays will have access to computers in order to undertake the required calculation, we do not consider that this will limit the usefulness of the MACS decision rule in a clinical setting.
In our calculations we did not use any special model of IGWs propagation.
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