Tables of chemical shift assignments, distance and dihedral angle restraints, structure calculation statistics and H−P HETCOR, natural abundance H−N HSQC, TOCSY, SNOESY, and NOESY spectra, and results of an unrestrained molecular dynamics simulation of 5′G AGC/3′C GAG.
Calculations, statistics and graphics were done by using Microcal Origin calculation software (version 5.0).
DYC provided assistance with the organization, calculations, statistics and writing of the manuscript.
HB performed programming of databases for all centres, data acquisition, data analysis, calculation of statistics and manuscript revision.
Sample size calculation, descriptive statistics, and explorative analyses were performed using the Mann–Whitney U Test. Twenty-nine children with SHCNs (21 boys, 9 girls; median age: 11 years, pre-treatment) and 29 children with NSHCNs (12 boys, 17 girls; median age: 12 years, pre-treatment) were enrolled in this study.
We will use three approaches to infer whether fester is experiencing selection or genetic drift: distribution of polymorphism within and among populations (AMOVA and FST calculations), polymorphism statistics, and ω statistics.
The GenStat (2011, 14th edition, © VSN International Ltd., Hemel Hempstead, UK) statistical package was used for the calculation of summary statistics, and analysis of variance (ANOVA) was used to test the overall significance (F-test) of differences between years using all the data.
Analyses included calculation of summary statistics and creation of multivariable logistic regression models.
PK was involved in the data analysis, calculation of the statistics and revision of the paper.
For calculation of summary statistics and graphical display, observed and simulated concentration data were categorized by rounded time after dosing.
We extracted outcomes data relevant to this review, as needed, for calculation of summary statistics and measures of variance.
