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This study group had been recruited based on a sample size calculation for finding a 6% difference in the risk of developing high-risk situations with 80% power and 5% two-sided type I error rate considering also a 5% protocol violation.
This calculation is based on finding a significant difference between the intervention and control arms in the primary outcome: the proportion of retained versus non-retained participants at 12 months.
This calculation is based on finding a significant difference between the intervention and control arms in the primary outcome: the proportion of participants who complete LTBI treatment versus those who do not.
PKSIM is based on finding interaction spots developed for docking calculations [2] and the maximal overlap thereof.
Most research effort in this field is focused on finding new biomarkers for which serum levels can be added to the risk calculation algorithm.
Focus on finding a solution.
When millions of dollars can be won or lost on one calculation, firms are finding it essential that their new hires can tell the difference between a pivot table and a header row.
Based on these calculations the probability of finding one ovarian cancer in the BRCA-1 mutation carrier group was 92% and the probability of finding one ovarian cancer in the BRCA-2 mutation carrier group was 8.7% (see Tables 5 and 6).
These findings were based on two calculations on case-finding percentages in the PN database.
We conducted a sensitivity analysis on data that did not require these calculations, finding a similar result but one that lacked statistical significance.
Judging on these calculations the probability of finding an ovarian cancer in the non- BRCA carriers is smaller than that for mutation carriers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com