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Follow-up period appropriate for the aim of the study Yes 1 Yes 1 7. Loss to follow-up less than 5%% Unclear 0.5 Unclear 0.5 8. Prospective calculation of study size No 0 No 0 9.
The number of patients enrolled was used in the calculation of study and patient demographics.
Statistician Leif Sandvik, Oslo University Hospital, contributed in the calculation of study sample and will contribute in the statistical analyses.
Another interesting tool for design evaluation, specifically for the calculation of study power and number of study subjects required, is Monte Carlo Mapped Power (mcmp).
The process of data synthesis is thus: (1) study selection following the literature search; (2) data extraction, including calculation of study weighting factors; (3) regression analysis.
Our primary outcome was experimental tumor volume and we extracted necessary information (sample size, mean measure of treatment effect, and SDM/SEM) to enable calculation of study and aggregate level effect sizes.
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Sample size calculation of this study was based on the study by Spijkervet Spijkervett et al, 1990).
For six non-randomised studies, 12 17 according to the modified MINORS criteria, 18 none of them reported an unbiased assessment of the study end point or a prospective calculation of the study size.
Follow-up period appropriate 2 2 0 0 0 0 1 2 0 0 0 2 7. Loss to follow-up less than 5%% 2 2 0 0 0 0 0 0 0 0 0 2 8. Prospective calculation of the study size 0 0 0 0 0 0 0 0 0 0 0 0 Additional criteria in the case of comparative study 9.
The power calculation of this study was based on the results of the Canadian adverse event study [ 1].
IBM SPSS Statistics ver.22 was used for k-means clustering and the calculation of all study areas (Fig. 2) converged to 40 clusters at the 682th iteration.
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