Functional site prediction was performed by the calculation of Meta-Functional Signature (MFS) scores for the fourteen modeled Hmd enzymes and paralogs [ 13].
Heterogeneity of effects across strata was assessed using meta-analytic techniques, including both graphical inspection and calculation of meta-analytic Q-statistics [ 25].
We explored heterogeneity of environmental effects by serogroup and by lethality of infection (fatal vs. nonfatal) using stratum-specific analyses, with heterogeneity of effects across strata assessed through calculation of the meta-analytic Q statistic (34).
Calculation of NNTs from meta-analytical estimates is not prone to the same bias.
We therefore examined the impact of type of correlation calculation in this meta-analysis.
Regardless of this complexity, effect size calculation and meta-analyses of different studies use the addition of scores from many disparate functions to provide a global score for problems like 'cognition', 'behavior', or 'activities of daily living'.
Four foot disease disorders met the prespecified minimum for meta-analysis calculation of three eligible studies with similar study designs.
The small number of studies and different pain outcome measures precluded meta-analysis, calculation of a summary estimate and exploration of sources of heterogeneity.
Studies reporting sufficient data to enable calculation of effect sizes were included in meta-analyses.
We will take into account this possible problem both by calculation of Hardy-Weinberg equilibrium and by meta-regression analysis.
However, calculation of pooled means across studies using meta-analytic techniques was not appropriate, given the high level of heterogeneity in terms of study design and patient characteristics.
