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Of all post-authorization NI trials that claimed additional benefit, 45% performed tests to show statistical significance, and only one included a pre-study sample size calculation for the additional claim.
Of all the post-authorization NI trials that claimed additional benefit, 10 out of 22 NI trials used formal statistical analyses to show additional benefit, and only one included a sample size calculation for the additional benefit prior to the trial.
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Sample size calculations for the additional two arms of the study resulted in an unusual 10 10 7 4 allocation ratio.
In 10 trials (45%), formal tests were used to explore statistical significance of the claimed additional benefit, but only one performed a sample size calculation for the claimed additional benefit prior to the start of the trial [ 7].
These calculations include costs for the additional labour required for pyrosequencing.
Moreover, this calculation does not account for the additional benefits that would result from the use of human cells and the integration of several organ models onto a single chip (Esch et al. 2011; Huh et al. 2010).
Matlab scripts were developed for the calculation of all the additional fields corresponding to parameters of vulnerability.
The ashmeters installed at this time (first generation) had a range of 0.3 – 10 mm and a resolution for thickness readings twice lower than the current model (fifth generation) used for the resolution calculation presented in the Additional file2.
An additional calculation for the risk-groups resulted in Kappa = 0.28 (95 % CI 0.23-0.55).
These physicochemical properties and the methods of calculation for the molecular sets are given in Additional file 1: Table S7.
It will be shown that writing the consistency conditions obtained from the equivalency between the atomistic crystal lattice dynamics of the bulk material and its counterpart in the second strain gradient elasticity is insufficient for the calculations of all the additional constants.
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