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We will select the active TFs by a q-value calculation described below.
The 12 subjects have been chosen among the 19 reported by Hinshaw et al. (10) since they had the complete CGM and CSII data required for the calculation described below.
For the v2 array design, which includes bacterial probes, an additional minimum sequence complexity constraint was enforced, requiring a trimer frequency entropy of at least 4.5 (calculation described below).
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L. Czechowski developed the 3D numerical model of the overturn and performed calculations described below.
In the calculations described below, the surface temperature is set to 1750 K (Table 1) for a solid body before impact and the temperature increase with depth (0.1 K/km, based on a lower-mantle temperature gradient Monnereau and Yuen 2002), is assumed to be linear.
We extracted 2500 structures from each MD simulation and all of these structures were used in the calculations described below unless otherwise stated.
The sampling duration was based on priori sample size calculations (described below).
Based on sample size calculations described below, we will enroll 4,500 patients across all sites.
The restraints mono_xray and mono_aria will be used as intra-monomer restraints during the ARIA calculations described below.
Some of the calculations described below can be run on a standard workstation in a reasonable time, while others require small computer clusters found at most universities.
In further calculations described below pH was set to 7. In Figs. 1e and 1f the logarithm of activity of water (log ) appears as a variable.
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