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Based on the determined uncertainties, we also identified main contributors to the calculation bias.
We acknowledge that the retrospective evaluation of TIL is a limitation of our study, and potential calculation bias cannot be excluded.
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Since 67% of all gene families contained only a single potential gene sequence (pHap) and thus displayed no sequence variation, we reasoned that their presence in the calculation biased the frequency estimate.
In these calculations, bias was calculated as the distance in color space between matches in the baseline condition and matches in the relevant experimental condition.
By Epstein's calculations, biased Google results could shift the vote in November by up to 2%, or about 2.6 million votes.
However, problematic incentives for participation in the calculation can bias the calculated costs; the G-DRG tariff calculation has a representativeness problem.
As a result the NIH calculation is bias against low-flow devices.
If the models could not be fitted and converged, their results were excluded from the calculation of bias and mean squared error (MSE).
The agreement between the methods was studied by the Bland and Altman method with calculation of bias and the limits of agreement [ 31].
In this calculation, the bias was not included because there were no sufficient data on the reference materials and/or proficiency samples.
We have added a comment about the length of peaks and our calculation of bias as discussed above in the text (in the subsection headed "DamID identification of NKX2-5 Wtargetetarget
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