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The third will examine the extent to which the trial design is informed by a sample size calculation based on previous data for the primary outcome instrument.
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Population growth rates of 0.05 and 0.07 were used for the calculations, based on previous data for European populations and on Galician historic census (http://www.ine.es/).es/
The sample size calculations based on previous data assumed the proportion of patients appropriately treated were 10% when based on clinical diagnosis and 60% when based on microscopy, one clinician per clinic, and variability between clinics of half of the mean effect of the diagnostic test on the outcome.
An unacceptable correlation was considered to be 0.3 (i.e. accounting for 9% of variance), and (based on previous data) a plausible correlation for purposes of power calculation was defined as 0.5 (or more).
Based on previous data from fingerprint-matched MTB, our power calculations explored a range of between-strain genetic distances (s) from 50 to 300 mutations [ 4].
Standard deviation was estimated based on previous data.
A previous NONMEM calculation, based on data from the four dismantlers only (Table 2, subjects A D), having initial BDE-209 levels much lower than the rubber workers, yielded the estimate of 7 days (95% CI, 3 16 days) (Sjödin 2000).
***Authors' calculation based on IDF data.
Other times, data is a calculation based on other data.
The power calculation was based on previous observational data of cholecalciferol supplementation in hemodialysis patients) [ 3].
†Our calculation based on data in publication.
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