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We acknowledge the valuable help of Dr Elias Castanas, University of Crete, Greece, who provided us the formula for calculating the dose of drug administration in vivo, from IC50 value, in vitro.
Body surface area (BSA), despite well-documented limitations, remains the most frequently used measure for calculating the dose of cytotoxic drugs in chemotherapy regimens[1], [2].
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Calculating the doses of meropenem on population pharmacokinetic models from patients without critically illness may thus under estimate antibiotic concentrations measured in real populations and result in unnecessarily high drug regimens.
Poor Mr. Rieff wound up entangled in the single biggest dilemma in medicine: how to calculate the dose of hope, that most powerful of all medications, to be dispensed in hopeless cases.
GlucoStabilizer™ is a software-guided insulin dosing system that calculates the dose of intravenous insulin needed based on metabolic parameters, target glucose concentration, and an individual's response to insulin.
The exact weight (Mettle AM100 scales) of the needle and syringe was detailed before and after introduction of the isotope into 20 ml of orange juice and used to calculate the dose of isotope administered to each child.
We used the estimated patient weight recorded for each patient to calculate the dose of FFP administered for each FFP transfusion episode in milligrams per kilogram.
Also, in this work we did not determine exercise load or ventilation rates and therefore could not calculate the dose of pollutants each participant inhaled.
A method was devised with which to calculate the dose of intervention planned and that is actually received (programme-driven activities dose), as well as the amount of non-planned intervention (non-programme-driven activities dose).
The aim of this study was to compare two methods, the serum concentration monitoring (SCM) and the nomogram of Moellering (NM), employed to calculate the dose of vancomycin (V) in the critically ill patient.
Considering the length of her body trunk is very close to that of normal adult, we speculated that we should not calculate the dose of anesthetics based only on her height.
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