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The links between targets are obtained by calculating sequence similarity between proteins and again examining the shared drugs.
When calculating sequence distances, it is important to clearly note how alignment gaps are dealt with.
Given the computational requirements, it is very difficult to test the robustness of the clustering method, for instance, by using a different set of BLAST parameters in calculating sequence similarities.
This greater evolutionary distance may cause signal loss when calculating sequence conservation statistics for Sz.
In the past different approaches like calculating sequence identity or molecule names were used to cross-reference identifiers.
This relationship was observed when using several different methods of calculating sequence similarity (Additional file 3: Figure S2).
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Using these assignments we have calculated sequence length distributions of ethylene and butylene sequences in the materials obtained.
To facilitate the interpretation of genome-wide polymorphism data, PoPoolation also calculates sequence divergence for closely related species pairs.
ClustalW [96] was used to calculate sequence identity between matches found between the testset of 1217 structural genomics proteins and their BLAST matches in SwissProt.
The BLOSUM62 matrix was used to calculate sequence homology scores.
Some machine learning methods utilize BLOSUMs to calculate sequence distances.
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