Therefore, we have calculated worst-case estimations for the device lifetime based on the number of transmissions that the designed process would yield for different configurations.
However, the agency has made no comment when TransCanada proposed the same mechanism for calculating worst case spills.
We also calculated the worst and best case ICERs based on the lower and upper 95% confidence limits of the incremental efficacy, respectively.
Addition of 7 mg/l from smoking one cigarette, calculated under worst case assumptions, is in the same order of magnitude as the physiological fructose level in the epithelial lining fluid.
The following data were collected from all study patients at study enrolment: age, sex, body mass index, admission diagnosis, and a modified Goris multiple organ dysfunction score [ 25] calculated from worst clinical and laboratory parameters on the day of study entry.
The Simplified Acute Physiology Score (SAPS) II [ 14] and Sequential Organ Failure Assessment (SOFA) score [ 15] were calculated from worst clinical parameters during the first 24 hours after intensive care unit admission (SAPS II) and throughout the intensive care unit stay (SOFA), respectively.
This PNEC is higher than published PECs (Singer et al. 2007) or those newly calculated using worst-case pandemic use assumptions and various algorithms.
